Effect of cocaine on the contractile response to noradrenaline in the epididymal and prostatic regions of the vas deferens
Berdysheva, L.V.; Kichikulova, T.P.; Manukhin, B.N.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 85(8): 1090-1094
1999
ISSN/ISBN: 0869-8139 PMID: 10643604 Document Number: 504308
In the prostatic half of the rat vas deferens, the response to noradrenaline under the cocaine effect revealed a phasic and a tonic components, whereas in the epididymal portion of the vas deferens there only occurred the tonic component. Cocaine increased the maximal tonic contractile response to noradrenaline in the epididymal portion and the maximal phasic response--in the prostatic one. Mechanisms of direct postsynaptic action of cocaine are discussed.