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The development of acute tolerance to analgesia and the sensitivity changes in mouse vas deferens and ileum produced by morphine

Ramaswamy, S.; Pillai, N.P.; Gopalakrishnan, V.; Ghosh, M.N.

Archives Internationales de Pharmacodynamie et de Therapie 261(2): 214-221

1983

ISSN/ISBN: 0003-9780
PMID: 6838282
Document Number: 209307
Repeated administration of morphine at 4 hr interval resulted in the development of tolerance to morphine-induced subsensitivity to acetylcholine in ileum and supersensitivity to norepinephrine in vas deferens of mouse. This was in parallel with analgesic tolerance to morphine. Pretreatment with naloxone antagonized the tolerance development to both morphine-induced analgesia and sensitivity changes, indicating a role for opiate receptors in this phenomenon.

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Ramaswamy, S.; Padmanabha Pillai, N.; Ghosh, M.N. 1981: Effect of morphine on the sensitivity of mouse vas deferens and ileum during chronic morphine treatment and its correlation with analgesic tolerance Archives Internationales de Pharmacodynamie et de Therapie 249(1): 39-51
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