Postoperative analgesia with morphine versus morphine and paracetamol. a double-blind clinically controlled study with a placebo
Jespersen, T.W.; Christensen, K.S.; Kjaersgaard-Andersen, P.; Sommer, S.; Juhl, B.
Ugeskrift for Laeger 151(25): 1615-1618
1989
ISSN/ISBN: 0041-5782 PMID: 2675432 Document Number: 339954
The effect of paracetamol on the postoperative employment of morphine was investigated in a double-blind clinically controlled investigation with a placebo. The operations concerned were elective gynaecological laparotomies and hip replacements. During the first 60 hours postoperatively, the employment of morphine was reduced significantly in the patients who received paracetamol. Reductions of 16, 22 and 26% were concerned. The differences between the various types of operation were not significant. Patients for joint replacements who had been treated preoperatively with non-steroid anti-inflammatory preparations did not have any significantly greater consumption of morphine postoperatively but the reduction in consumption of morphine in the paracetamol group was significantly greater with a saving of 43%. Patients who had received treatment with morphine preparations preoperatively had significantly greater consumption of morphine postoperatively but the additive analgesic effect of paracetamol remained unchanged at approximately 25%.