Double-blind controlled comparison of placebo and paracetamol in patients with G-6-PD deficiency
Cottafava, F.; Nieri, S.; Franzone, G.; Sanguinetti, M.; Bertolazzi, L.; Ravera, G.
La Pediatria Medica e Chirurgica Medical and Surgical Pediatrics 12(6): 631-637
1990
ISSN/ISBN: 0391-5387 PMID: 2093885 Document Number: 4008
In this study are reported 17 patients with G-6-PD deficiency. These subjects have been studied with double-blind trial between placebo and Paracetamol, looking for the possible hemolysis induced from drug in these children with G-6-PD deficiency. Hemolysis had been valued by various hematological parameters (Hb, erythrocyte count, reticulocytosis, bilirubinemia, haptoglobin, hemopexin, and survival of erythrocytes marked with Cr). The results (8 cases with placebo and 9 cases with paracetamol) demonstrate that paracetamol have not induced hemolysis in these G-6-PD deficient subjects.
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