Development of acute morphine tolerance in peripheral clinico-chemical parameters
Héber, S.; Markó, E.; Kovács, G.L.
Acta Physiologica Hungarica 78(1): 11-18
1991
ISSN/ISBN: 0231-424X PMID: 1763647 Document Number: 381411
Changes in peripheral clinico-chemical parameters packed cell volume (PCV), hemoglobin (HGB), serum glucose, carbamide-nitrogen (CN), and creatinine were investigated in mice during the development of acute morphine tolerance. Acute morphine treatment (in drug-naive organism) altered the PCV, HGB, serum glucose and CN levels in a naloxone-reversible manner. Acute tolerance developed in PCV, HGB and CN values. The data raise the possibility of a relationship between clinico-chemical and pharmacological tolerance.