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Effect of morphine on the sensitivity of mouse vas deferens and ileum during chronic morphine treatment and its correlation with analgesic tolerance

Ramaswamy, S.; Padmanabha Pillai, N.; Ghosh, M.N.

Archives Internationales de Pharmacodynamie et de Therapie 249(1): 39-51

1981

ISSN/ISBN: 0003-9780
PMID: 7194622
Document Number: 173111
Supersensitivity to norepinephrine (NE) in vas deferens and to acetylcholine (ACh) in ileum was observed during chronic morphine treatment and precipitated withdrawal in mice. Analgesic tolerance and sensitivity changes during chronic morphine exposure followed a biphasic pattern demonstrating a positive correlation between them. Potassium chloride (KCl)-induced response remained unaffected. A high degree of supersensitivity to ACh was evident during naloxone precipitated withdrawal suggesting a greater involvement of ACh in the withdrawal phenomenon. The results support the theory proposed by Collier, to explain tolerance and dependence.

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Ramaswamy, S.; Pillai, N.P.; Gopalakrishnan, V.; Ghosh, M.N. 1983: The development of acute tolerance to analgesia and the sensitivity changes in mouse vas deferens and ileum produced by morphine Archives Internationales de Pharmacodynamie et de Therapie 261(2): 214-221
O'Callaghan, J.P.; Holtzman, S.G. 1976: Prenatal administration of morphine to the rat: tolerance to the analgesic effect of morphine in the offspring Journal of Pharmacology and Experimental Therapeutics 197(3): 533-544
Satoshi, I.; Narita, M.; Ozeki, A.; Nakamura, A.; Hashimoto, S.; Narita, M.; Kuzumaki, N.; Uezono, Y.; Suzuki, T. 2008: Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state Nihon Shinkei Seishin Yakurigaku Zasshi 28(5-6): 169-176
Brown, N.J.; Coupar, I.M.; Rumsey, R.D. 1988: The effect of acute and chronic administration of morphine and morphine withdrawal on intestinal transit time in the rat Journal of Pharmacy and Pharmacology 40(12): 844-848
Vetrilé, L.A.; Basharova, L.A.; Igon'kina, S.I.; Trekova, N.A.; Evseev, V.A. 1993: The effect of catecholamine and serotonin antibodies on pain sensitivity and the development of morphine tolerance in experimental drug addiction Biulleten' Eksperimental'noi Biologii i Meditsiny 116(11): 453-455
Smith, M.T.; Nielsen, C.K.; Lim-Fraser, M.Y.; Wright, A.W.; Lau, M. 2000: Systemic coadministration of chloramphenicol with intravenous but not intracerebroventricular morphine markedly increases morphine antinociception and delays development of antinociceptive tolerance in rats Drug Metabolism and Disposition: the Biological Fate of Chemicals 28(2): 236-244
Kasson, B.G.; George, R. 1981: Effects of growth hormone and prolactin on morphine sensitivity and tolerance Proceedings of the Western Pharmacology Society 24: 319-321
Imai, S.; Narita, M.; Hashimoto, S.; Nakamura, A.; Miyoshi, K.; Nozaki, H.; Hareyama, N.; Takagi, T.; Suzuki, M.; Narita, M.; Suzuki, T. 2006: Differences in tolerance to anti-hyperalgesic effects between chronic treatment with morphine and fentanyl under a state of pain Nihon Shinkei Seishin Yakurigaku Zasshi 26(5-6): 183-192
Mignat, C.; Jansen, R.; Ziegler, A. 1995: Plasma and cerebrospinal fluid concentrations of morphine and morphine glucuronides in rabbits receiving single and repeated doses of morphine Journal of Pharmacy and Pharmacology 47(2): 171-175
Uchihashi, Y.; Kuribara, H.; Morita, T.; Kitani, Y.; Karasawa, F.; Sato, T. 1996: Differential effects of morphine-6-glucuronide, an active metabolite of morphine, and morphine on locomotor activity in mice: involvement of the opioid receptor Pharmacology and Toxicology 78(5): 322-326
French, E.D.; Vasquez, S.A.; George, R. 1976: Acute and chronic effects of morphine and withdrawal from morphine on temperature in the cat Proceedings of the Western Pharmacology Society 19: 273-277
Mattila, M.J. 1979: Analgesic and morphine enhancing effect of psychotropic drugs Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 99(22): 996-998
Hasnain, F.; Janbaz, K.H.; Qureshi, M.A. 2012: Analgesic effect of ketamine and morphine after tonsillectomy in children Pakistan Journal of Pharmaceutical Sciences 25(3): 599-606
Sato, T.; Yagishita, Y.; Tamaru, M.; Mitsuse, T.; Sugiura, Y.; Fukuda, K.; Kano, T.; Morioka, T. 1980: Intrathecal application of morphine. IV. Analgesic effect on the pain in the head Masui. Japanese Journal of Anesthesiology 29(10): 1057-1062
Malec, D.; Michalska, E. 1990: The effect of adenosine receptor agonists on analgesic effects of morphine Polish Journal of Pharmacology and Pharmacy 42(1): 1-11
Kovalev, I.E.; Zvartau, E.E.; Lavretskaia, E.F.; Metkalova, S.E.; Basharova, L.A. 1981: Effect of active immunization of rats with a bovine serum albumin-morphine conjugate on morphine consumption Farmakologiia i Toksikologiia 44(2): 200-204
Sudakov, S.K.; Liupina, I.V.; Medvedeva, O.F.; Tiurina, I.V. 1997: The effect of bradykinin, vasopressin and ACTH (4-10) on the morphine withdrawal syndrome in morphine-dependent rats of 2 inbred strains Eksperimental'naia i Klinicheskaia Farmakologiia 60(4): 14-16
Czlonkowski, A.; Kostowski, W. 1977: Factors which might modify analgesic effect of morphine in differentially housed rats Polish Journal of Pharmacology and Pharmacy 29(2): 117-121
Han, Y.-Y.; Lu, H.-C.; Tsai, H.-J.; Hseu, S.-S.; Chan, K.-H.; Tsai, S.-K. 2003: The analgesic effect of oral morphine or pentazocine for extracorporeal shock wave lithotripsy Acta Anaesthesiologica Sinica 41(1): 27-32
Mohanakumar, K.P.; Sood, P.P. 1985: Inhibitory action of morphine on adenosine triphosphatase content in the whole and individual nuclei of mouse brain during the tolerance-dependence development and its reversal by naloxone Journal für Hirnforschung 26(6): 695-708