Determination of the degradation product, p-aminobenzoic acid, in procaine hydrochcloride injections
Zhang, J.X.; Yu, R.G.
Yao Xue Xue Bao 21(9): 712-715
1986
ISSN/ISBN: 0513-4870 PMID: 3495097 Document Number: 280030
A .DELTA.P2 method is presented for the determination of the degradation product, p-aminobenzoic acid, in procaine-HCl injections. With phosphate buffers of, pH 2.90 and pH 7.50 as solvents, the .DELTA.P2 coefficient calculated over the wavelength range 228.6 .apprx. 288.6 nm at 12 nm intervals using 6 point quadratic orthogonal polynomial is independent of procaine-HCl. Mean percent recovery for 9 separate determinations was 100.4 .+-. 2.4. This method is simple and the results obtainted are reliable. The proposed method can also be used to detect the limit amount of PABA in procaine-HCl injections.