A simple and practical method for isolation of an early plasmin degradation product of human fibrinogen
Takagi, K.; Kawai, T.
Thrombosis and Haemostasis 37(3): 464-470
1977
ISSN/ISBN: 0340-6245 PMID: 142313 Document Number: 118566
One of the earliest plasmin degradation products of human fibrinogen, so-called fragment A, was isolated by a simple method. This peptide has a molecular weight of approximately 22,500, migrating electrophoretically at beta-area, and its amino acid composition shows a very high content of glycine, serine, threonine and proline, and a markedly low content of hydrophobic amino acids. This fragment does not react against anti-fibrinogen; however, the anti-serum of this fragment reacts strongly with fibrinogen.