Relation between the hypotensive effect of triampur and its pharmacokinetics in patients with hypertension
Kuznetsov, G.P.; Lebedev, P.A.
Kardiologiia 26(3): 49-52
1986
ISSN/ISBN: 0022-9040 PMID: 3712933 Document Number: 276333
The hypotensive effect of triampur was studied in 39 patients with first- and second-stage essential hypertension, as was the pharmacokinetics of triamterin, the main constituent of triampur. A relationship is demonstrated between the curve area, blood triamterin peak, clearance and cumulative excretion, on the one hand, and the hypotensive effect, on the other. Triamterin pharmacokinetic studies may be used for the screening of hypertensive patients as potential candidates for triampur treatment. Alongside other causes, low blood concentrations of the drug in the course of treatment may be associated with its low efficiency.