Antihypertensive effects and pharmacokinetics of NZ-105 single administration in patients with hypertension
Yokoyama, S.; Kaburagi, T.; Mori, N.; Sakata, K.; Yoshida, H.; Hoshino, T.
Nihon Jinzo Gakkai Shi 34(2): 199-205
1992
ISSN/ISBN: 0385-2385 PMID: 1588771 Document Number: 402989
The influence of renal function on the antihypertensive effect and pharmacokinetics of NZ-105 were studied in 7 patients with essential hypertension (EH) and 6 patients with hypertension having impaired renal function (RH). 1. As for the hypertensive effect, both in EH and RH, the maximum antihypertensive effect was attained 3 to 5 hr after drug administration and there was not significant difference between EH and RH. 2. There was not significant difference in transition of plasma concentration of NZ-105 between EH and RH. 3. Concerning pharmacokinetic parameters of NZ-105, there was significant difference between EH and RH in Tmax. at 20 mg of NZ-105 administration. However, in regard to Tmax. at 30 mg of NZ-105 administration and Cmax., AUC and t1/2 at 20 mg, 30 mg of NZ-105 administration, there were not significant differences between EH and RH. 4. There was no correlation between t1/2 and serum creatinine levels. 5. All cases showed good tolerance without any adverse effect.