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Pharmacokinetics of rifampicin in single and repeated administration to patients with inflammatory processes in the lungs of nontuberculotic etiology

Makarenkova, R.V.; Kopeiko, I.P.

Antibiotiki 22(3): 259-260

1977

ISSN/ISBN: 0003-5637
PMID: 848920
Document Number: 123194
Rifampicin is a broad spectrum semisynthetic antibiotic of the group of rifampicins. It is active against both grampositive and gramnegative organisms and mycobacteria. The studies on the pharmacokinetics of rifampicin showed that the drug was well absorbed from the gastro-intestinal tract. After a single administration of rifampicin in a dose of 150 mg its maximum concentration in the blood was registered in an hour. This concentration was preserved at the therapeutic level for 5 hours. Practically no accumulation of rifampicin was observed in its use in a dose of 150 mg 4 times a day for 5 days. Perspectivity of rifampicin use in the treatment of patients with inflammatory processes in the lungs of non-tuberculosis etiology was shown.

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