Amino acid composition and biological action of a peptide bioregulator from bovine k-casein
Stan, E.I.; Zhuravlev, B.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 102(12): 652-655
1986
ISSN/ISBN: 0365-9615 PMID: 3801611 Document Number: 273716
Peptide material has been first isolated from k-casein pepsin hydrolysate. Its subcutaneous injection to hungry animals induced high amplitude (250-350 mV) and high frequency (16-20 Hz) oscillations of electrical potentials usually observed in food satiety and cholecystokinin administration. The peptide reduced respiratory and to a lesser extent heart rate. Its effect is temporary eliminated by naloxone. According to an aminogram, the peptide is a fragment of para-k-casein. A neurotropic peptide effect is connected with satiety regulation and milk consumption in the postnatal period.