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Effect of a single ethanol administration on the permeability of the hemato-encephalic barrier for 14C-tyrosine, 14C-DOPA and horseradish peroxidase

Burov, I.V.; Borisenko, S.A.; Kiianmaa, K.; Lehtosalo, J.; Mannisto, P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 101(3): 331-334

1986

ISSN/ISBN: 0365-9615
PMID: 3082384
Document Number: 272380
Single injection of ethanol at a dose of 2 and 4 g/kg has been shown to increase blood-brain barrier penetration for peripherally administered 14C-tyrosine and 14C-DOPA. No changes in blood-brain barrier penetration for horseradish peroxidase has been found. Acute effect of ethanol on blood-brain barrier systems of specific and nonspecific transport is discussed.

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