Specific brain antigens--an index of the permeability of the hemato-encephalic barrier in comatose states in children
Lidzhieva, R.Ts.; Berestov, A.I.; Chekhonin, V.P.; Blokhin, B.M.; Korobko, L.M.
Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 88(8): 25-28
1988
ISSN/ISBN: 0044-4588 PMID: 2461625 Document Number: 326070
In 39 children with coma caused by infectious toxicosis, purulent meningoencephalitis and closed head trauma the brain-specific antigens (L1M and L2M globulins) contents were studied in the blood serum and cerebrospinal fluid (CSF). On days 3 to 5 after the head trauma L1M and L2M were found irregularly. In meningoencephalitis L1M and L2M were detected with a lesser delay. In infectious toxicosis L1M and L2M appeared in blood serum and CSF regularly and early. The data suggest that appearance of brain-specific antigens in blood and CSF in coma reflect a rise in the blood-brain barrier permeability to CSF-blood transport.