Experimental and clinical data on the ability of bemetil to penetrate the hemato-encephalic barrier

Boĭko, S.S.; Bobkov, I.G.; Dobrokhotova, T.A.; Kniazeva, N.A.; Neznamov, G.G.

Farmakologiia i Toksikologiia 50(3): 79-81

1987


ISSN/ISBN: 0014-8318
PMID: 3609285
Document Number: 4127
Experimental and clinical data indicated bemetil ability to penetrate through the blood-brain barrier. Bemetil concentration in the rat brain tissue was found to be significantly higher than in the plasma. Its concentration in the cerebrospinal fluid of patients with craniocerebral trauma was lower than in the plasma; the latter however does not exclude the possibility of bemetil accumulation in the brain structures.

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Experimental and clinical data on the ability of bemetil to penetrate the hemato-encephalic barrier