Bemetil pharmacokinetics in an experiment on rats
Boĭko, S.S.; Bobkov, I.G.; Zherdev, V.P.; Dvorianinov, A.A.
Farmakologiia i Toksikologiia 50(5): 54-56
1987
ISSN/ISBN: 0014-8318 PMID: 3691781 Document Number: 3815
Pharmacokinetics of bemetil (2-ethyl-mercaptobenzimidazole), a representative of the group of actoprotectors, was studied at intravenous and intragastric administration during the experiment on rats by using gas-liquid chromatography. It was found that at intragastric administration the drug rapidly appeared in the systemic circulation, reached the maximal concentration in one hour; the character of bemetil elimination from the blood was biexponential at both routes of administration. The two-compartment model was used for calculation of the main pharmacokinetic constants and bioavailability. The analysis of the experimental findings on urinary excretion of bemetil made it possible to conclude that little amount of the drug (0.56%) is excreted in the urine in the unchanged form; most amount of bemetil is excreted in the form of metabolites and in the bound state.
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