Effects of oophorectomy on trabecular bone mineral content in the rat
Barbagallo, M.; Carbognani, A.; Pedrazzoni, M.; Pioli, G.; Girasole, G.; Gelmini, G.; Palummeri, E.
Bollettino della Societa Italiana di Biologia Sperimentale 62(10): 1191-1195
1986
ISSN/ISBN: 0037-8771 PMID: 3828117 Document Number: 269903
The effects of oophorectomy on the vertebral bone mineral content of Sprague-Dawley rats were studied by means of a new sensitive and accurate technique, the dual photon absorptiometry. The results show a significant decrease of the bone density of the lumbar spine four months after the surgical castration, compared with bone density of sham operated rats, and suggest that this method may be applied to the study of the pathogenesis of osteoporosis in this animal model.