Oophorectomy did not show any additional effect on bone density and mineral content in thyroxine treated mice
Broulik, P.D.; Pacovský, V.; Límanová, Z.
Endocrinologia Experimentalis 23(1): 49-53
1989
ISSN/ISBN: 0013-7200 PMID: 2714227 Document Number: 341192
Experimental hyperthyroidism (thyroxine administration for 21 days) caused a significant decrease in ash mass, bone density and mineral content in the femora of mice, the same degree of reduction in individual measures of bone mass being found in oophorectomized and intact mice treated with thyroxine. It may be suggested that estrogens did not protect the skeleton against the resorbing action of thyroxine or triiodothyronine.
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