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Changes in mineral content and biochemical bone markers at the menopause

Mazzuoli, G.; Minisola, S.; Valtorta, C.; Antonelli, R.; Tabolli, S.; Bigi, F.

Israel Journal of Medical Sciences 21(11): 875-877

1985

ISSN/ISBN: 0021-2180
PMID: 4077482
Document Number: 248088
Serum alkaline phosphatase activity, serum bone .gamma.-carboxyglutamic acid protein, urinary hydroxyproline and bone mineral content were simultaneously measured in 30 age-matched pre- and postmenopausal women in order to define the temporal relationship between skeletal turnover and bone loss. In postmenopausal women, mean values of phosphatase activity, serum bone .gamma.-carboxyglutamic acid protein and urinary hydroxyproline were significantly higher, and mean values of mineral content were significantly lower than in premenopausal women. A marked loss of bone mineral content together with a persistent increase in skeletal turnover is already evident shortly after the menopause.

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