Treatment of postmenopausal osteoporosis with salmon calcitonin nasal spray: evaluation by bone mineral content and biochemical patterns
Tolino, A.; Romano, L.; Ronsini, S.; Riccio, S.; Montemagno, U.
International Journal of Clinical Pharmacology Therapy and Toxicology 31(7): 358-360
1993
ISSN/ISBN: 0174-4879 PMID: 8370634 Document Number: 413187
We studied 21 women with postmenopausal osteoporosis, treated with salmon calcitonin nasal spray (100 IU/daily) and calcium (1 g/daily) for six months. Bone mineral content (BMC), measured before and at the end of therapy with lumbar dual photon absorptiometry, showed a significant increase (p < 0.01). At the end of the study, there was also a clear improvement of osteoporotic pain. Among biochemical markers of bone turnover, there was a significant (p < 0.01) reduction of urinary excretion of hydroxyproline. No side effect was registered and all patients had a good compliance to therapy.