Effect of ubiquinone on phospholipid metabolism in radiation injury
Novoselova, E.G.; Kolomiĭtseva, I.K.; Obol'nikova, E.A.; Samokhvalov, G.I.; Kuzin, A.M.
Biulleten' Eksperimental'noi Biologii i Meditsiny 99(4): 440-442
1985
ISSN/ISBN: 0365-9615 PMID: 3986368 Document Number: 264738
The synthesis and phospholipid content in the liver, intestine and spleen in normal and irradiated rats administered ubiquinone-9 were studied with the use of 3H-serine. Ubiquinone markedly activated decarboxylase of phosphatidylserine and suppressed transformation of phosphatidylethanolamine to phosphatidylcholine in rat liver and spleen. The effect was also observed in the organs of irradiated animals. In rat intestine, administration of ubiquinone normalized a sharp .gamma.-irradiation-induced inhibition of transformation of phosphatidylcholine from phosphatidylethanolamine. The catabolism of phospholipids under the action of ubiquinone and radiation was inhibited in the liver and, on the contrary, was activated in radiosensitive organs.