Synthesis of cyclic and non-cyclic tachykinin partial sequences. 2. Synthesis of the homocyclic substance P (6-11) hexapeptide
Neubert, K.; Hartrodt, B.; Mehlis, B.; Rüger, M.; Bergmann, J.; Lindau, J.; Jakubke, H.D.; Barth, A.
Die Pharmazie 40(8): 532-535
1985
ISSN/ISBN: 0031-7144 PMID: 2417264 Document Number: 263777
The authors describe the synthesis of Gln-Phe-Phe-Gly-Leu-Met by cyclization of H-Leu-Met-Gln-Phe-Phe-Gly using three different methods. The linear sequence was obtained by a (2+4)-segment condensation. The resulting cyclopeptide showed only a small kinin activity on isolated guinea pig ileum compared to substance P, but it is a full agonist.