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Synthesis and some biological properties of the hexapeptide analog of substance P with a C-terminal thioamide group

Kruszyński, M.; Kupryszewski, G.; Misterek, K.; Gumułka, S.

Polish Journal of Pharmacology and Pharmacy 42(5): 483-490

1990

ISSN/ISBN: 0301-0244
PMID: 1711685
Document Number: 358302
A new hexapeptide analog of Substance P, containing a C-terminal thioamide group in the molecule [( Glp6, Mett11]SP6-11) was synthesized: Glp-Phe-Phe-Gly-Leu-Mett-NH2. Conversion to thioamide was accomplished from tert-butoxycarbonyl-L-methionine amide (Boc-Met-NH2) using Lawesson's Reagent. Its contracting activity on isolated guinea-pig ileum was considerably lower than that of [Glp6]SP6-11.

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