Dipyridamole as an inhibitor of vaccinia virus replication
Korbecki, M.; Bankowski, A.; Filczak, K.; Klimek, A.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 1: 29-32
1985
ISSN/ISBN: 0208-0613 PMID: 3842738 Document Number: 262962
Dipyridamole in concentration of 25 microM inhibited the multiplication of vaccinia virus in about 90% of cells. In the presence of this substance, [3H]-uptake was sharply reduced both in uninfected and infected RK13 cells, while [14C]-uptake was not inhibited incorporation of [3H]-thymidine and [14C]-amino acids into viral particles. The present findings suggest that the antiviral character of dipyridamole is related with the inhibition of the substrate transport through the cell membrane.