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Acetaldehyde metabolism in liver injury

Hobara, N.

Arukoru Kenkyu to Yakubutsu Izon 20(1): 9-27

1985

ISSN/ISBN: 0389-4118
PMID: 4038168
Document Number: 262457
Acetaldehyde metabolism in liver injury induced by administration of carbon tetrachloride or D-galactosamine was studied in rats using pentobarbital as an anesthetic which had least effect on ethanol metabolism. In acute liver injury and in regnerating liver after partial hepatectomy as a repair model of liver injury, high levels of acetaldehyde concentration in both the blood and liver after ethanol administration were derived from the decrease in aldehyde dehydrogenase activity in the liver mitochondrial fraction. When cyanamide and ethanol were administered to normal rats to maintain the liver acetaldehyde level at high concentrations (50-750 .mu.M), liver mitochondrial injury, such as an increase in serum ornithine carbamoyltransferase activity or an increase in liver triglyceride contents was not recognized. Necrosis of liver cells or fat accumulation in the liver was not observed histologically. The accumulation of acetaldehyde in the liver is apparently not a causal and promoting factor of alcoholic liver injury but lowering of liver aldehyde dehydrogenase activity occurs as a result of liver injury.

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Earnest, D.L.; Sim, W.W.; Smith, T.L.; Eskelson, C.D. 1990: Ethanol, acetaldehyde and Kupffer cell function: potential role for Kupffer cells in alcohol induced liver injury Progress in Clinical and Biological Research 325: 255-265
Kattermann, R.; Sirowej, H. 1979: Liver injury and lipid metabolism: sex differences in the fatty liver induced by d-galactosamine Acta Hepato-Gastroenterologica 26(2): 112-121
Saarni, H.U.; Savolainen, E.R.; Sotaniemi, E.A. 1983: Effect of medroxyprogesterone acetate on liver collagen and drug metabolism in rats after chemical liver injury Research Communications in Chemical Pathology and Pharmacology 42(1): 61-69
Riveros-Rosas, H.; Julian-Sanchez, A.; Pinã, E. 1997: Enzymology of ethanol and acetaldehyde metabolism in mammals Archives of Medical Research 28(4): 453-471
Kurata, N.; Kemper, R.; Hurst, H.E.; Waddell, W.J. 1990: Inhibition of the metabolism of ethyl carbamate by acetaldehyde Drug Metabolism and Disposition: the Biological Fate of Chemicals 18(4): 504-507
Szukalski, B.; Szczepańska-Szewczyk, M. 1986: Biochemical aspects of alcoholism. III. the effect of acetaldehyde on cellular metabolism Postepy Higieny i Medycyny Doswiadczalnej 40(2): 191-219
Bardina, L.R.; Satanovskaia, V.I.; Pron'ko, P.S.; Kuz'mich, A.B. 1997: Activity of the enzymes of ethanol and acetaldehyde metabolism in rats with varying initial sensitivity to alcohol Ukrainskii Biokhimicheskii Zhurnal 69(1): 94-99
Sarafov, D.; Mitkov, D.; Dzhambazova, S. 1994: Effect of a balanced amino acid-based diet on the nitrogen metabolism in carbon tetrachloride-induced liver injury Folia Medica 36(1): 13-20
Aleryani, S.; Kabakibi, A.; Cluette-Brown, J.; Laposata, M. 1996: Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury Clinical Chemistry 42(1): 24-27
Nilius, R.; Königstedt, B.; Zipprich, B.; Busse, H.J.; Lorenz, G. 1982: Acetaldehyde-induced leukocyte migration inhibition in alcoholic liver diseases Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 37(12): 393-397
Solomon, L.R.; Crouch, J.Y. 1990: Delta-Aminolevulinic acid dehydratase in rat liver: studies on the effects of ethanol, acetaldehyde, and B6 vitamers Journal of Laboratory and Clinical Medicine 116(2): 228-236
Shiohara, E.; Tsukada, M.; Chiba, S.; Yamazaki, H.; Nishiguchi, K.; Nakanishi, S. 1986: Effect of acute acetaldehyde inhalation on rat liver microsomal mixed function oxidase system Arukoru Kenkyu to Yakubutsu Izon 21(3): 216-223
Shiraishi, K.; Tsuruya, K.; Anzai, K.; Arase, Y.; Hirose, S.; Kagawa, T.; Mine, T.; Matsuzaki, S. 2015: Effects of ethanol and acetaldehyde load on erythrocyte deformability in healthy subjects and patients with liver cirrhosis Nihon Arukoru Yakubutsu Igakkai Zasshi 50(1): 13-18
Lacroix, E.; Eechaute, W. 1978: Estradiol metabolism in normal and cirrhotic rat liver. I. Estradiol metabolism in perfused liver and in liver sections Verhandelingen - Koninklijke Academie Voor Geneeskunde van Belgie 40(4): 269-316
Bolognesi, M.; Merkel, C.; Angeli, P.; Caregaro, L.; Gatta, A. 1988: Liver metabolism of indocyanine green and aminopyrine in liver cirrhosis: relations with functioning liver cell mass Minerva Medica 79(12): 1035-1041
Zhuang, J.; Wang, Z.; Liu, J.; Gou, L. 2004: Putative mechanism of experimental immunological liver injury and influence of iron low-load on the injury in rat Wei Sheng Yan Jiu 33(6): 687-689
Matiushin, I.F.; Boiarinov, G.A.; Bogdarin, I.A. 1981: Effect of nerobolil on higher fatty acid metabolism in the rat liver normally and in disordered protein metabolism Voprosy Meditsinskoi Khimii 27(5): 604-607
Kaledin, V.I.; Il'nitskaia, S.I. 2011: Metabolism inhibition stimulates, metabolism activation inhibits cancerogenic activity of ortho-aminoazotoluene in mouse liver Voprosy Onkologii 57(2): 216-220
Pennington, S.N.; Chattopadhyay, S.K.; Brown, H.D. 1970: A possible pathway for ethanol-induced fatty liver and modification of liver injury by antioxidants Quarterly Journal of Studies on Alcohol 31(1): 13-19
Swerdlow, M.A.; Chowdhury, L.N. 1984: IgA deposition in liver in alcoholic liver disease. An index of progressive injury Archives of Pathology and Laboratory Medicine 108(5): 416-419