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Transmembrane potential and electrogenicity of thrombocyte Na, K-ATPase in different forms of hypertension in rats

Kravtsov, G.M.; Postnova, N.A.; Postnov, I.V.

Biulleten' Eksperimental'noi Biologii i Meditsiny 100(8): 174-176

1985

ISSN/ISBN: 0365-9615
PMID: 2992629
Document Number: 261519
The fluorescent dye 3,3'-dipropylthiadicarbocyanine iodide, dis-C3-(5), was used to study the membrane potential of platelets in rats with renal, DOCA-induced and spontaneous hypertension. The magnitude of the transmembrane potential in platelets combines the activity of electrogenic Na, K-ATPase and the rate of ion diffusion across the plasma membrane. The basal potential is 12 = 14 mB as lowered only in spontaneously hypertensive rats. The decrease of the basal potential is made for electrogenicity of platelet Na, K-ATPase in spontaneously hypertensive rats.

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