Effect of serotonin on the yield of UV- and x ray-induced DNA damage
Ivanova, E.V.; Fraĭkin, G.I.
Biokhimiia 50(8): 1374-1376
1985
ISSN/ISBN: 0320-9725 PMID: 3907724 Document Number: 261173
Using two-dimensional thin-layer chromatography, the effect of serotonin on the yield of thymine dimers and on cleavage of the N-glycosidic bond in the DNA irradiated with ultraviolet (UV) light and X-ray was studied. Bound serotonin was shown to reduce the synthesis of UV-induced thymine dimers but had no effect on the number of X-ray-induced breaks in the N-glycoside bonds in thymidine residues. The data obtained are discussed in terms of the mechanisms of serotonin involvement in the photoprotection of yeast cells from the lethal action of UV and X-ray irradiations.