Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo (a) pyrene
Chen, X.; Han, R.
Chinese Medical Sciences Journal 10(1): 16-19
1995
ISSN/ISBN: 1001-9294 PMID: 7780111 Document Number: 446759
Glycyrrhetinic acid (GA) is an active component of Glycyrrhiza uraleusis fisch. In this study, GA was found to inhibit ear edema and ornithine decarboxylase (ODC) activity induced by croton oil in mice. GA could also protect rapid DNA damage and decrease the unscheduled DNA synthesis induced by benzo(a)pyrene. The results demonstrate that GA has a potential cancer chemopreventive activity.
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