Induced nucleophilic substitution in benzo (a) pyrene
Johnson, M.D.; Calvin, M.
Nature 241(5387): 271-272
1973
ISSN/ISBN: 0028-0836 PMID: 4701885 Document Number: 68266
Cavalieri and Calvin have proposed1,2 that the carcinogenic action of benzopyrene (Ba P) may arise from aryl hydroxylase induced binding to nucleophilic cellular components. Their theory proposes that attack by electrophilic oxygen, produced in the hydroxylase system, occurs at the 6 position of the hydrocarbon to give a carbonium ion, localized primarily at the 1 and 3 positions, which can undergo attack with nucleophilic cellular components. Alternatively, initial attack could occur at 1 or 3, followed by nucleophilic reaction at.