Inhibition of chemotactic activity of leucocytes by pregnancy serum
Datta, U.; Rayat, C.S.; Dhall, K.; Sehgal, S.
Indian Journal of Medical Research 81: 157-161
1985
ISSN/ISBN: 0019-5340 PMID: 4007966 Document Number: 255822
Chemotactic activity of the normal leukocytes in the presence of serum from pregnant women was measured using the Wilkinson's modification of the Boyden's chamber. Sera were collected from 17 normal females and 23 primigravida in the last trimester of pregnancy. While chemotaxis remains unaffected by 15% of normal serum, there was a significant decline (P < 0.001) of this activity on exposure to sera collected in the last trimester from primigravida. This effect was more marked (P < 0.001) in the subsequent pregnancies. The inhibitor was labile as its activity diminished on storage at -20.degree. C for 70 days.