Clinical studies of cefpiramide in obstetrics and gynecology
Ishikawa, M.; Shimizu, T.
Japanese Journal of Antibiotics 38(8): 2338-2341
1985
ISSN/ISBN: 0368-2781 PMID: 4079006 Document Number: 254067
In vivo transfer and therapeutic efficacy of a new cephalosporin derivative, cefpiramide (CPM) were studied in the perinatal and gynecologic fields. The following results have been obtained. 1. The level of CPM transferred to uterus and adnexa was higher than its MIC against majority of Gram-negative bacilli, such as Escherichia coli. 2. This drug demonstrated its efficacy in treating 3 infection cases refractory to cephalothin, ampicillin and cephalexin, out of which 1 had "excellent" and 2 had "good" results. 3. No side effect was evidenced in any of our patients. In conclusion, this drug has satisfactory tissue transfer as well as sufficient safety and excellent efficacy in the treatment of perinatal infection cases.