Some effects of imidocarb in goats
Ali, B.H.; Hassan, T.; Suliman, H.B.; Abdelsalam, E.B.
Veterinary and Human Toxicology 27(6): 477-480
1985
ISSN/ISBN: 0145-6296 PMID: 4082455 Document Number: 252495
Clinically normal Nubian goats were given imidocarb at single i/m doses of 6, 12, 18 and 24 mg/kg, and the various clinical, biochemical and pathological manifestations were recorded. A dose of 6 mg/kg produced no changes. Higher doses produced dose-dependent changes which included increased heart and respiratory rates, increased defaecation, urination, depression, incoordination of movement, weakness of the hindlegs, recumbency, and finally death. Just before death, there was a significant decrease in the number of erythrocytes, packed cell volume, and haemoglobin concentration. In plasma there was an increase in the activity of aspartate transaminase and in the urea and creatinine concentrations and an inhibition of cholinesterase activity. The main histopathological changes were associated with hepatic and renal damage. Three goats were pre-treated with atropine sulphate (1 mg/animal) and after one hour given imidocarb intramuscularly at a dose of 12 mg/kg. The changes were similar but much less severe than in animals given imidocarb alone at the same dose.