Effect of sodium methyl arsinate and imidocarb dipropionate antiprotozoal drugs on the pharmacokinetic of gentamicin in equines
Soliman, G.A.
Deutsche Tierärztliche Wochenschrift 105(7): 274-276
1998
ISSN/ISBN: 0341-6593 PMID: 9697352 Document Number: 494983
The pharmacokinetic behaviour of gentamicin sulphate (3.4 mg/kg bwt) was studied following its intramuscular injection to a group of horses and to another group of horses premedicated with sodium methyl arsinate (2 mg/kg bwt) or imidocarb dipropionate (4.8 mg/kg bwt). Considerable differences were observed in the pharmacokinetics of gentamicin in pre-medicated horses and in horses which had received the antibiotic alone. Peak serum concentration of gentamicin (9.85 +- 0.05 and 11.15 +- 0.15 pg/ml) were attained within 1.45 +- 0.05 and 0.92 +- 0.04 h in arsinate and imidocarb-medicated horses, respectively, but reached a level of 9.18 +- 0.07 pg/mL at 1.87 +- 0.12 h in non-medicated animals. Gentamicin elimination half-life (+- 0.5 (el)) was faster in arsinate (7.82 +- 0.31 h) and imidocarb (6.12 +- 0.14 h) pre-medicated horses than in non medicated horses (9.88 +- 0.19 h). In addition, the interval between doses (Ibd) necessary to maintain a therapeutic level were shorter in the pre-medicated animals. In summary, the hypothesis that the pharmacokinetics of gentamicin are altered by concomitant therapy with antiprotozoal drugs was confirmed by this study.