Experimental and pharmacokinetic studies with gentamicin PMMA beads
Wahlig, H.; Dingeldein, E.; Bergmann, R.; Reuss, K.
Zentralblatt für Chirurgie 104(14): 923-933
1979
ISSN/ISBN: 0044-409X PMID: 494864 Document Number: 150389
Gentamicin PMMA beads (PMMA = polymethylmethacrylate) represent a new form of local antibiotic therapy for treating chronic bone and soft tissue infections. Gentamicin is released in high concentrations from PMMA. The therapeutic efficacy of the beads was demonstrated in a model of bone infection in dogs. Sufficiently high tissue concentrations of gentamicin were measurable for a period of 4 months. A very good tolerance of the beads was demonstrated in dogs as well as in cell cultures. High gentamicin concentrations exceeding the MBC values of relevant pathogens were measurable in patients at the site of infection. Serum and urine concentrations were low and therefore toxic side effects are excluded.