Chemical drug delivery systems: I. Preparation and evaluation of prodrugs of dapsone
Kulkarni, V.M.; Mishra, D.S.
Indian Journal of Leprosy 57(4): 756-762
1985
ISSN/ISBN: 0254-9395 PMID: 3835207 Document Number: 251257
Several prodrugs of dapsone have been prepared and evaluated in vivo for the release of parent drug. The prodrug: 4,4'-dibutyrylaminodiphenyl sulfone gave blood levels above 0.5 micrograms/ml of DDS for about 34 days in rabbits injected intragluteally. The results have been compared with DDS and DADDS.