Antiherpetic activity of xylure
Chekunova, E.V.; Marennikova, S.S.; Mel'nik, S.Ia.; Preobrazhenskaia, M.N.; Zaguliaeva, O.A.
Voprosy Virusologii 30(4): 444-446
1985
ISSN/ISBN: 0507-4088 PMID: 3904209 Document Number: 249400
In vivo experiments demonstrated antiherpetic activity of abnormal nucleoside, 5-trimethylsylil-2'-deoxyuridine .alpha.-anomer. In a model of herpetic encephalitis in cotton rats the preparation, inoculated intraperitoneally and administered orally, reduced the lethality by 25%-30% as compared with the controls, and also was effective in topical treatment of genital herpes in guinea pigs. Low toxicity, clear-cut antiherpetic activity, favorable metabolic properties as compared with known antiherpetic drugs indicate the necessity of further thorough investigation of this preparation.