Effect of furosemide, hypothiazide and urea on the physicochemical properties of blood serum proteins in rats
Strelianaia, E.I.; Voloshin, P.V.; Bozhko, G.Kh.
Farmakologiia i Toksikologiia 48(2): 86-89
1985
ISSN/ISBN: 0014-8318 PMID: 3996576 Document Number: 247199
It has been shown by gel chromatography and electrophoresis in polyacrylamide gel that single and chronic therapeutic doses of furosemide and hypothiazide did not alter the structure of rat blood serum proteins. The exception was a single administration of hypothiazide that provoked the formation of labile protein associations. Administration of urea to the animals resulted in the formation of large stable aggregations of serum proteins. The associations contained albumin, transferrin, immunoglobulins and group-specific proteins situated on the electrophoregram between transferrin and albumin.