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Effect of chemical radioprotectors on serum proteins of rats exposed to gamma radiation

Srinivasan, M.N.; Basu, S.K.; Ghose, A.

Indian Journal of Experimental Biology 23(9): 490-492

1985

ISSN/ISBN: 0019-5189
PMID: 3833690
Document Number: 255742
Paper electrophoretic fractions of serum proteins were made prior to and at one, three and seven days following exposure of rats to 11 Gy whole body .gamma.-irradiation. During the early period of post irradiation an increase in total proteins, a decrease in albumin and .gamma.-globulin fractions and an increase in .alpha. and .beta. fractions were observed. On 7th day of post irradiation there was a drastic decrease in total proteins and in all the fractions. Similar studies carried out in animals pre-treated with radioprotectors (other than MPG) reduced considerably the changes produced by .gamma.-irradiation on total proteins and its fractions except albumin. Combinations of .beta.-mercaptopropionylglycine + 5-hydroxy L-tryptophan (5-HTP), 2-aminoethylisothiuronium bromide hydrochloride (AET) + 5-HTP and the optimum dose of AET (200 mg/kg body wt.) gave better protection than 5-HTP and accelerated the normalization process of the altered serum proteins of irradiated rats.

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