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Structure and properties of the cell nucleus chromatin in the brain of rats exposed to gamma-radiation

Chaialo, P.P.; Protas, A.F.

Ukrainskii Biokhimicheskii Zhurnal 64(3): 34-38

1992

ISSN/ISBN: 0201-8470
PMID: 1440963
Document Number: 397128
Exposure of rats to radiation in a dose of 1 Gy changes sensitivity of chromatin in the cerebral cortex to the action of DNAase 1, which promotes an increase of the DNA hydrolysis level and content of dissolved chromatin fractions. A day after irradiation the chromatin structure restores only partially and then (7-30 days after irradiation) it passes into a new, less compact state. The irradiation changes the chromatin ability to aggregation in the presence of Mg2+ and spermidine.

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