Comparison of the physicochemical properties of model immune complexes from normal and myeloma proteins
Konstantinova, N.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 103(2): 176-178
1987
ISSN/ISBN: 0365-9615 PMID: 3814798 Document Number: 290874
Physico-chemical properties of model immune complexes from normal and myeloma immunoglobulins were compared, and complement-binding activity of these aggregates was studied. No considerable differences were observed between aggregates from normal and myeloma Ig. Myeloma complexes have a higher complement-binding activity, as compared to normal ones, and are structurally more stable. Complement-binding activity of both types of complexes depends on the complex molecular mass and is maximal in complexes of medium molecular mass.