Complement-binding activity of myeloma and normal immune complexes
Lavrent'ev, V.V.; Konstantinova, N.A.; Tumanova, I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 101(2): 183-185
1986
ISSN/ISBN: 0365-9615 PMID: 3947736 Document Number: 275084
The comparison of complement-fixing capacity of simulated immune complexes formed by normal IgG and IgG, isolated from serum of patients with multiple myeloma, has been performed. In both cases a non-linear dependence of complement-fixing capacity on the complex molecular mass was demonstrated, it being higher for myeloma proteins. Complement supplementation to high molecular complexes leads to their collapse, with normal immune complexes destroyed at lower molecular masses. Heat-aggregation of myeloma immunoglobulins leads to the formation of simulated immune complexes of lower molecular mass compared to normal proteins.