Potential vaccine antigens of the asexual blood-stages of Plasmodium falciparum
Anders, R.F.; Brown, G.V.; Coppel, R.L.; Stahl, H.D.; Bianco, A.E.; Favaloro, J.M.; Crewther, P.E.; Culvenor, J.G.; Kemp, D.J.
Developments in Biological Standardization 62: 81-89
1985
ISSN/ISBN: 0301-5149 PMID: 2422079 Document Number: 244709
An extensive library of antigen-expressing cDNA clones which includes a large number of distinct P. falciparum asexual blood-stage antigens has been prepared. Sequencing studies on the clones showed that many malaria antigens contain extensive sequence repeats. The repeats encode antigenic epitopes which in several proteins have been shown to be immunodominant. Ring-infected erythrocyte surface antigen (RESA) and falciparum interspersed repeat antigen (FIRA) are described.
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