Mouse foot-pad studies with M. leprae--effect of desoxy fructo serotonin (DFS) and related compounds
Balakrishnan, S.; Mester, L.; Venkataramaniah, H.N.; Bhatia, V.N.
Indian Journal of Leprosy 57(2): 323-328
1985
ISSN/ISBN: 0254-9395 PMID: 3908578 Document Number: 244266
Mouse foot-pad experiments were carried out to study the effects of DFS and related compounds on the multiplication of M. leprae. Of the 25 cases clinically suspected Dapsone resistance, 8 were found resistant and 14 sensitive to Dapsone by mouse foot-pad experiments. Six were resistant to DFS and 16 were sensitive. Desoxy fructo 5-hydroxy tryptophane as well as Nutrition Antileprosy (NAL) diet were also found effective in suppressing the growth of M. leprae in mouse foot-pad. Of the two liposoluble derivatives of DFS tested (DFS LS-I and DFS LS-II), DFS LS-II was found more effective in suppressing the growth of M. leprae in foot-pads of mice.