Efficacy of a drug combination of praziquantel, pyrantel pamoate, and febantel against giardiasis in dogs
Barr, S.C.; Bowman, D.D.; Frongillo, M.F.; Joseph, S.L.
American Journal of Veterinary Research 59(9): 1134-1136
1998
ISSN/ISBN: 0002-9645 PMID: 9736391 Document Number: 243
Objective-To evaluate efficacy of a combination of praziquantel, pyrantel pamoate, and febantel at 2 dosages for treating naturally acquired giardiasis in dogs. Animals-6 male and 9 female Beagles. Procedure-Dogs were identified as naturally infected with Giardia sp, using the zinc sulfate concentration technique (ZSCT), and were allocated to 1 of 3 groups. Group-1 dogs were treated orally with a praziquantel (5.4 to 7 mg/kg of body weight), pyrantel pamoate (26.8 to 35.2 mg/kg), and febantel (26.8 to 35.2 mg/kg) combination, every 24 hours for 3 doses. Group-2 dogs were treated with the combination once. Group-3 dogs were nontreated controls. Four fecal samples were examined, using the ZSCT, from each dog of each group within 6 days of the last treatment. Dogs were considered to have giardiasis if 1 or more of the fecal samples had positive results for Giardia cysts. Dogs were examined daily for at least 10 days after the last treatment. Results-Giardia cysts were not detected in the feces of any group-1 dog or in the feces of 2 of 5 group 2 dogs. Cysts were detected in the feces of 5 of 5 group-3 (nontreated control) dogs. Signs of toxicosis were not observed in any dog. Conclusion and Clinical Relevance-The current labeled dose (for treatment of various nematodes and cestodes, but not Giardia sp) of the combination given orally once reduces cyst excretion in Giardia-infected dogs, and should be considered for treatment of dogs shedding Giardia cysts, whether or not they have clinical signs of infection.
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