Use of the immunofluorescence reaction for evaluating the immunological transformation in those inoculated with a chemical typhus vaccine
Rydkina, E.B.; Shirokova, E.M.; Balaeva, N.M.; Kokorin, I.N.; Nikol'skaia, V.N.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 11: 78-82
1985
ISSN/ISBN: 0372-9311 PMID: 3937396 Document Number: 242152
The results of the serological examination of persons immunized with chemical typhus vaccine (CTV) are presented. The examination was carried out by means of the complement fixation test (CFT), the passive hemagglutination test (PHAT), the toxin neutralization test (TNT) and the immunofluorescence test (IFT). The acetone-fixed live culture of Rickettsia prowazekii, strain Breinl, served as antigen in IFT. If persons immunized with CTV showed positive titers in CFT, TNT and PHAT, the results of IFT were highly correlated with the CFT titers. In 6-12 months after immunization with CTV the titers of CFT, TNT and PHAT became negative, while the IFT titers remained positive for several subsequent years.