Effect of hyperbaric oxygenation on experimental scrapie in mice
Roikhel, V.M.; Fokina, G.I.; Sobolev, S.G.; Korolyev, M.B.; Pogodina, V.V.
Acta Virologica 28(4): 294-299
1984
ISSN/ISBN: 0001-723X PMID: 6148854 Document Number: 241446
The effect of hyperbaric oxygenation upon experimental infection of BALB/c mice with the scrapie agent was investigated by virological methods, histology and electron microscopy. A multiple exposure of scrapie-infected mice to hyberbaric oxygenation during the incubational period led to a certain aggravation of infection as evidenced by a greater accumulation of the agent in the central nervous system (CNS) and spleen, as well as by more pronounced ultramicroscopic changes in CNS. A single exposure to hypoxia failed to alter any manifestations of infection.