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Effect of hyperbaric oxygenation on the corticosterone content of the blood in experimental acute respiratory distress syndrome

Rogatskiĭ, G.G.; Golikov, P.P.; Nikolaeva, N.I.; Vaĭnshteĭn, M.B.

Biulleten' Eksperimental'noi Biologii i Meditsiny 107(5): 545-547

1989

ISSN/ISBN: 0365-9615
PMID: 2736282
Document Number: 331038
The three series of experiments conducted on 139 adult wistar rats it was found, that two-hour stay of the animals in barochamber under the pressure of 3 atmospheres reduces considerably the percentage of mortality rate and decelerates the development of arterial hypoxemia in rats with an experimental model of acute respiratory distress syndrome (ARDS) reproduced by intrapleural injection of oleic acid (0.27 ml/100 g). Stalle in comparison with the control (I) series elevation of corticosterone in the animal blood II and III series (conduction of HBO correspondingly in 4 and 12 hours from the beginning of the process) is considered as the manifestation of one of the most important mechanism of organism adaptation to the development of acute hypoxia in ARDS.

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