Experimental studies on the pathogenesis of acute respiratory distress syndrome
Cai, Y.Z.; Zhang, B.R.; Zhu, J.L.; Cai, K.H.; Mao, Z.N.; Jia, Z.Q.; Fu, J.Z.; Ye, J.W.; Yu, J.R.
Chinese Medical Journal 98(7): 528-537
1985
ISSN/ISBN: 0366-6999 PMID: 3932020 Document Number: 253490
In this article the authors study the pathogenesis of acute respiratory distress syndrome (ARDS) by reasearching into the characteristics of alveolar microcirculation of animals. Three experiments are done for the effects of various factors: a. Outlet resistance of alveolar microcirculation; b. intra-arteriolar microemboli; and c. pressure gradient between the alveolar microvascular pressure(P)and the alveolar pressure (PAL) on the development of lung injury in ARDS. The experimental results show that increase of P is primarily responsible for, while pressure gradient between P and PAL is the essential condition for the development of alveolar tissue damage. Whenever the two factors coexist, damage of alveolar tissues will inevitably occur. The essence of the pathogenesis of ARDS is that inflow of alveolar microcirculation outweighs the outflow, causing the increase of P value and damage of alveolar tissues.