Activation of human complement by crude and purified antigens from Echinococcus granulosus
Perricone, R.; De Carolis, C.; Grimaldi, O.; Fontana, L.
La Ricerca in Clinica E in Laboratorio 14(1): 65-72
1984
ISSN/ISBN: 0390-5748 PMID: 6427882 Document Number: 241441
Hydatid cyst fluid (Echinococcus granulosus) interacted with human complement. This interaction resulted in the depletion of hemolytic complement in normal serum and in the electrophoretic conversion of C3 and factor B. The results provided evidence of an activation of complement via the alternative pathway when hydatid cyst fluid was used in the mixtures. Purified hydatid antigen preparations were found to interact with complement in vitro; this interaction resulted in the consumption of complement not only by the alternative pathway, but also by the classical pathway.