Lipid peroxidation of the blood neutrophils of patients with an ischemic insult and myocardial infarct and of their relatives
Davidenkova, E.F.; Shafran, M.G.; Grigor'eva, V.V.; Kolosova, N.N.; Liberman, I.S.
Klinicheskaia Meditsina 62(11): 79-81
1984
ISSN/ISBN: 0023-2149 PMID: 6521384 Document Number: 240024
The function of the neutrophil blood lipid peroxidation system was studied in patients with atherosclerosis complicated by coronary insult or myocardial infarction (30 patients), the patients relatives of the 1st and 2nd degree kinship (39 subjects) and in the control group of subjects with non-aggravated heredity as regards atherosclerosis (38 subjects). The in vitro application of the test with adrenaline loading of neutrophil leukocytes has demonstrated that the function of the system of peroxide lipid oxidation is disturbed in patients and their relatives as compared to the control group. Since these changes were also found in phenotypically healthy relatives of atherosclerosis patients they are apparently genetically determined and can be detected in the preclinical stage of a pathological process.